Abstract:
:CpG dinucleotides are efficiently methylated in vertebrate genomes except in the CpG islands having a high C+G content. Methylated CpGs are the single most mutated dinucleotide. Sequences surrounding disease causing CpG mutation sites were analyzed from locus-specific mutation databases. Both tetra- and heptanucleotide analyses indicated clear overall sequence preference for having pyrimidines 5' and purines 3' to the mutated 5-methylcytosine. The most mutated tetranucleotides are TCGA and TCGG, the former being also a frequent restriction and modification site. The results will help in elucidating the still controversial mutation mechanism of CpG doublets.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ollila J,Lappalainen I,Vihinen Mdoi
10.1016/0014-5793(96)01075-7subject
Has Abstractpub_date
1996-11-04 00:00:00pages
119-22issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(96)01075-7journal_volume
396pub_type
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