Abstract:
:Accumulation of hyperphosphorylated Tau is associated with a number of neurodegenerative diseases collectively known as tauopathies. Differences in clinical and cognitive profiles among them suggest differential sensitivity of neuronal populations to Tau levels, phosphorylation and mutations. We used tissue specific expression of wild type and mutant human tau transgenes to demonstrate differential phosphorylation and stability in a cell type-specific manner, which includes different neuronal types and does not correlate with the level of accumulated protein. Rather, they likely reflect the spatial distribution or regulation of Tau-targeting kinases and phosphatases.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Grammenoudi S,Kosmidis S,Skoulakis EMdoi
10.1016/j.febslet.2006.07.045subject
Has Abstractpub_date
2006-08-21 00:00:00pages
4602-6issue
19eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00878-7journal_volume
580pub_type
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