Abstract:
:The astroglial growth factor (AGF), which induces a characteristic morphological change in cultured rat astroglial cells and stimulates their proliferation, was purified to homogeneity from bovine brain. Two different methods were used, the second one including heparin-Sepharose affinity chromatography. AGF is actually composed of two factors, AGF1 and AGF2, which both modify the morphology and stimulate the proliferation of the astroglial cells. Several data suggest that the AGFs are similar or possibly identical to the fibroblast growth factors (FGFs) isolated from brain [(1984) Proc. Natl. Acad. Sci. USA 81, 357-361; and 6963-6967]. A specific antiserum against AGFs was raised in mouse.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Pettmann B,Weibel M,Sensenbrenner M,Labourdette Gdoi
10.1016/0014-5793(85)80851-6subject
Has Abstractpub_date
1985-09-09 00:00:00pages
102-8issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(85)80851-6journal_volume
189pub_type
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