Abstract:
:Three of four natural compounds, which are caffeic acid, eupatilin and 4'-demethyleupatilin, isolated from Chinese plant, Artemisia rubripes Nakai selectively inhibited 5-lipoxygenase of cultured mastocytoma cells. Half-inhibition doses (ID50) for caffeic acid, eupatilin and 4'-demethyleupatilin were 3.7, 14 and 18 X 10(-6) M, respectively. The inhibition by caffeic acid was non-competitive types. Prostaglandin synthase activities were little inhibited by eupatilin and 4'-demethyleupatilin, but rather stimulated by caffeic acid. The formation of leukotriene C4 and D4 by mast tumor cells was almost completely suppressed by these compounds at 10(-4) M.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Koshihara Y,Neichi T,Murota S,Lao A,Fujimoto Y,Tatsuno Tdoi
10.1016/0014-5793(83)80672-3subject
Has Abstractpub_date
1983-07-11 00:00:00pages
41-4issue
1eissn
0014-5793issn
1873-3468journal_volume
158pub_type
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