Abstract:
:Platelet aggregation is accompanied by the tyrosine phosphorylation of several proteins including syk. However, some of these proteins are not identified. Recent studies showed that LAT is a syk substrate and is tyrosine phosphorylated during T cell stimulation. In this study, we demonstrated that LAT is present in platelets and is tyrosine phosphorylated in response to ADP- and thrombin-stimulated aggregation. Moreover, LAT, like syk and beta3, translocates to the cytoskeleton during the late stage of thrombin-stimulated irreversible aggregation and not during ADP-stimulated reversible aggregation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sarkar Sdoi
10.1016/s0014-5793(98)01584-1subject
Has Abstractpub_date
1998-12-28 00:00:00pages
357-60issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(98)01584-1journal_volume
441pub_type
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