Abstract:
:We have measured SGLT1 mRNA content and SGLT1-mediated glucose transport at different positions along the small intestine of control and streptozotocin diabetic rats and shown both parameters to be similar but higher in jejunal compared with ileal tissue. No such correlation was seen when comparing measurements of SGLT1 mRNA along jejunal villi with previous estimates of SGLT1 protein and SGLT1-mediated glucose transport [Debnam et al., Eur. J. Physiol. 430 (1995) 151-159]. This is the first time it has been possible to directly relate these three aspects of SGLT1 gene expression in a single species. Results are discussed in terms of a possible time rather than positional control over translation of SGLT1 mRNA.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Dong R,Srai SK,Debnam E,Smith Mdoi
10.1016/s0014-5793(97)00246-9subject
Has Abstractpub_date
1997-04-07 00:00:00pages
79-82issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(97)00246-9journal_volume
406pub_type
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