Abstract:
:The role of tRNA in translating the genetic code has received considerable attention over the last 50 years, and we now know in great detail how particular amino acids are specifically selected and brought to the ribosome in response to the corresponding mRNA codon. Over the same period, it has also become increasingly clear that the ribosome is not the only destination to which tRNAs deliver amino acids, with processes ranging from lipid modification to antibiotic biosynthesis all using aminoacyl-tRNAs as substrates. Here we review examples of alternative functions for tRNA beyond translation, which together suggest that the role of tRNA is to deliver amino acids for a variety of processes that includes, but is not limited to, protein synthesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Banerjee R,Chen S,Dare K,Gilreath M,Praetorius-Ibba M,Raina M,Reynolds NM,Rogers T,Roy H,Yadavalli SS,Ibba Mdoi
10.1016/j.febslet.2009.11.013subject
Has Abstractpub_date
2010-01-21 00:00:00pages
387-95issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00906-5journal_volume
584pub_type
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