Abstract:
:A cytosolic calmodulin wave has been described in the pre-replicative phase of rat liver regeneration. Here we demonstrate that this calmodulin increase is reduced by injection of cycloheximide (translation inhibitor) and actinomycin D (transcription inhibitor). In addition, we found that calmodulin mRNA levels are increased during the early pre-replicative period of liver regeneration, and this increase is affected by actinomycin D. Together, these results strongly indicate that the calmodulin wave observed in the pre-replicative phase of liver regeneration is due to de novo synthesis of this protein.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Piõl MR,Berchtold MW,Bachs O,Heizmann CWdoi
10.1016/0014-5793(88)80868-8subject
Has Abstractpub_date
1988-04-25 00:00:00pages
445-50issue
2eissn
0014-5793issn
1873-3468journal_volume
231pub_type
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