Abstract:
:Histone deacetylase 6 (HDAC6) is a multi-substrate cytoplasmic enzyme that regulates many important biological processes. Recently, some reports have implicated HDAC6 in viral infection. However, nothing is known about its regulation in virus-infected cells. The data presented here for the first time demonstrate the caspase-3-mediated cleavage of HDAC6 in influenza A virus (IAV)-infected cells. HDAC6 polypeptide contains the caspase-3 cleavage motif DMAD-S at the C-terminus, and is a caspase-3 substrate. The cleavage removes most of the C-terminal ubiquitin-binding zinc finger domain from HDAC6, which could be significant for HDAC6's role in IAV-induced apoptosis in infected cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Husain M,Harrod KSdoi
10.1016/j.febslet.2009.07.005subject
Has Abstractpub_date
2009-08-06 00:00:00pages
2517-20issue
15eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00530-4journal_volume
583pub_type
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