Abstract:
:The Kv3.1 channel plays a crucial role in regulating the high-frequency firing properties of neurons. Here, we determined whether Src regulates the subcellular distributions of the Kv3.1b channel. Co-expression of active Src induced a dramatic redistribution of Kv3.1b to the endoplasmic reticulum. Furthermore, co-expression of the Kv3.1b channel with active Src induced a remarkable decrease in the pool of Kv3.1b at the cell surface. Moreover, the co-expression of active Src results in a significant decrease in the peak current densities of the Kv3.1b channel, and a substantial alteration in the voltage dependence of its steady-state inactivation. Taken together, these results indicate that Src kinase may play an important role in regulating membrane trafficking of Kv3.1b channels.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bae SH,Kim DH,Shin SK,Choi JS,Park KSdoi
10.1016/j.febslet.2013.11.010subject
Has Abstractpub_date
2014-01-03 00:00:00pages
86-91issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00844-2journal_volume
588pub_type
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