Abstract:
:In this study, we demonstrated that laminin-1 (LM-1) induces neurite outgrowth and enhances the expression of neurofilament-L and MAP2 in human bone marrow mesenchymal stem cells (MSCs). The c-Jun transcription factor was strongly activated by LM-1 during neurite induction. Suppression of c-Jun inhibited the expression of the c-Jun target genes α6 integrin and neurofilament-L, resulting in the loss of neurite outgrowth. Additionally, we found that the LM-1-α6 integrin interaction stimulated phosphorylation of FAK, leading to the activation of JNK and Akt. Pharmacological inhibition of these pathways blocked c-Jun activation and neurite outgrowth. Collectively, our findings suggest that c-Jun/AP-1 activity mediated by JNK, PI3K/Akt and ERK pathways is required for LM-1-induced neurite outgrowth in human bone marrow MSCs.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mruthyunjaya S,Rumma M,Ravibhushan G,Anjali S,Padma Sdoi
10.1016/j.febslet.2011.04.072subject
Has Abstractpub_date
2011-06-23 00:00:00pages
1915-22issue
12eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00347-4journal_volume
585pub_type
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