Abstract:
:Botulinum neurotoxins (BoNTs), the causative agent of human botulism, are the most potent naturally occurring toxins known. BoNT/A1, the most studied BoNT, is also used as an important biopharmaceutical. In this study, the biological activity of BoNT/A1 is compared to that of BoNT/A2 using neuronal cell models. The data obtained indicate faster and increased intoxication of neuronal cells by BoNT/A2 than BoNT/A1, and that the mechanism underlying this increased toxicity is faster and more efficient cell entry that is independent of ganglioside binding. These results have important implications for the development of new BoNT based therapeutics and BoNT countermeasures.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Pier CL,Chen C,Tepp WH,Lin G,Janda KD,Barbieri JT,Pellett S,Johnson EAdoi
10.1016/j.febslet.2010.11.045subject
Has Abstractpub_date
2011-01-03 00:00:00pages
199-206issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00963-4journal_volume
585pub_type
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