Abstract:
:Previously determined protein structures have been analysed, in order to find folding motifs similar to that proposed by NMR spectroscopy, for the N-terminal, 14 kDa fragment of the Ada protein. The analyses reveal only limited similarities with the NMR-derived structural data and strongly suggest that this region of the Ada protein adopts a previously unobserved topology. Characteristic structural features, which arise from the inferred chain connectivity, are examined through comparisons with other structures. Using this information, the topology of the Ada protein 14 kDa fragment has been predicted in order to provide structural data not yet attainable from NMR experiments.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Swindells MBdoi
10.1016/0014-5793(93)81352-zsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
257-60issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(93)81352-Zjournal_volume
323pub_type
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