Abstract:
:Rho-associated kinase 2 (Rock2) is known to promote tumorigenesis in hepatocellular carcinoma (HCC). CCAAT/enhancer-binding protein delta (CEBPD) functions as a tumor suppressor. In this study, we found that the expression of Rock2 and CEBPD are inversely correlated. Knockdown of Rock2 increased CEBPD expression and inhibited the proliferation of HCC cells in vitro and in vivo. Mechanistically, we found that Rock2 regulates CEBPD expression through the p-GSK3β/β-catenin pathway. Taken together, we identified a novel Rock2-p-GSK3β/β-catenin-CEBPD regulatory circuitry, the dysfunction of which may contribute to the tumorigenic characteristic of HCC.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Li M,Zhou W,Yuan R,Chen L,Liu T,Huang D,Hao L,Xie Y,Shao Jdoi
10.1016/j.febslet.2015.03.004subject
Has Abstractpub_date
2015-04-13 00:00:00pages
1018-25issue
9eissn
0014-5793issn
1873-3468pii
S0014-5793(15)00142-8journal_volume
589pub_type
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