Abstract:
:Malignant mesothelioma (MM) is a fatal type of cancer. We studied the role of the redox-active protein thioredoxin-1 (Trx-1) in apoptosis induced in MM cells and their non-malignant counterparts (Met-5A) by alpha-tocopheryl succinate (alpha-TOS) and TNF-related apoptosis-inducing ligand (TRAIL). MM cells were susceptible to alpha-TOS and less to TRAIL, while Met-5A cells were susceptible to TRAIL and resistant to alpha-TOS. MM cells expressed very low level of the Trx-1 protein, which was high in Met-5A cells, while the level of Trx-1 mRNA was similar in all cell lines. Downregulation of Trx-1 further sensitised Met-5A cells to TRAIL but not to alpha-TOS. Our data suggest that the role of Trx-1 in apoptosis modulation is unrelated to its anti-oxidant properties.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Freeman RE,Neuzil Jdoi
10.1016/j.febslet.2006.04.019subject
Has Abstractpub_date
2006-05-15 00:00:00pages
2671-6issue
11eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00440-6journal_volume
580pub_type
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