Abstract:
:Previously, we cloned rat MRP3 as a candidate for an inducible transporter for the biliary excretion of organic anions [Hirohashi et al. (1998) Mol. Pharmacol. 53, 1068-10751. In the present study, we cloned human MRP3 (1527 amino acids) from Caco-2 cells. Human MRP3 is predominantly expressed in liver, small intestine and colon; hepatic expression of MRP3 was observed in humans but not in normal rats. In HepG2 cells, the expression of MRP3 was induced by phenobarbital. These results suggest that MRP3 may act as an inducible transporter in the biliary and intestinal excretion of organic anions.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kiuchi Y,Suzuki H,Hirohashi T,Tyson CA,Sugiyama Ydoi
10.1016/s0014-5793(98)00899-0subject
Has Abstractpub_date
1998-08-14 00:00:00pages
149-52issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00899-0journal_volume
433pub_type
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