Molecular mechanism of inhibition of mammalian protein synthesis by some four-chain agglutinins. Proposal of an extended classification of plant ribosome-inactivating proteins (rRNA N-glycosidases).

Abstract:

:The four chain agglutinins from Abrus precatorius, Viscum album and Ricinus communis promote depurination of the 28 S rRNA from rabbit reticulocyte ribosomes characteristic of the common ribosome-inactivating proteins (RIPs). These agglutinins inhibited mammalian protein synthesis at nanomolar concentrations but they do not affect plant protein synthesis under the same conditions. Therefore, they should also be considered as true RIPs but of a new class, the four-chain RIPs. An extended classification of RIPs is presented based on the former one from Stirpe et al. [Bio/technology 10 (1992) 405-412].

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Citores L,Ferreras JM,Iglesias R,Carbajales ML,Arias FJ,Jiménez P,Rojo MA,Girbés T

doi

10.1016/0014-5793(93)80193-x

subject

Has Abstract

pub_date

1993-08-23 00:00:00

pages

59-62

issue

1-2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(93)80193-X

journal_volume

329

pub_type

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