Abstract:
:The Ca2+-binding parvalbumin has been purified for the first time from rat kidney. Its biochemical and immunological properties were indistinguishable from the muscle counterpart. By immunohistochemical methods parvalbumin was localized in part of the distal tubule and proximal collecting duct, similar to the vitamin D-dependent Ca2+-binding protein, calbindin-28K. Parvalbumin was found to be independent of the vitamin D status of the animal since its concentration remained unchanged in kidney extracts of normal, rachitic and vitamin D-replete rats. Both proteins may be involved in the regulation of intracellular Ca2+ in kidney.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Schneeberger PR,Heizmann CWdoi
10.1016/0014-5793(86)80569-5subject
Has Abstractpub_date
1986-05-26 00:00:00pages
51-6issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(86)80569-5journal_volume
201pub_type
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