Abstract:
:Stroke is characterized by massive inflammation in areas surrounding the injury that magnifies damage to the brain. The liver X receptors (LXRs) are nuclear receptors that regulate cholesterol, lipid, and glucose metabolism. Synthetic LXR agonists have potent anti-inflammatory properties in a variety of settings, including neuroinflammation. However, the ability of LXR agonists to suppress stroke-associated inflammation has not been evaluated. Here, we have used time-lapse magnetic resonance imaging (MRI) to show that a single dose of an LXR ligand administered post-injury dramatically reduces brain damage in a model of acute brain ischemia. Neuroprotection was associated with suppression of neuroinflammation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sironi L,Mitro N,Cimino M,Gelosa P,Guerrini U,Tremoli E,Saez Edoi
10.1016/j.febslet.2008.08.035subject
Has Abstractpub_date
2008-10-15 00:00:00pages
3396-400issue
23-24eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00728-Xjournal_volume
582pub_type
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