Abstract:
:Bleomycin-reactive iron was detected in the sera of six out of nine adults undergoing intensive chemotherapy for acute non-lymphocytic leukemia. In these individuals the corresponding transferrin saturation ranged from 96% to 113% and the serum ferritin from 775 to 9975 micrograms/l. Nontransferrin-bound iron has been postulated to be a factor in organ toxicity in iron overload conditions such as beta thalassemia and hereditary hemochromatosis by facilitating the production of tissue-damaging free radicals. We propose that bleomycin-reactive iron should be considered as a possible factor in organ dysfunction seen with intensive cancer chemotherapy.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gordeuk VR,Brittenham GMdoi
10.1016/0014-5793(92)81037-mkeywords:
subject
Has Abstractpub_date
1992-08-10 00:00:00pages
4-6issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(92)81037-Mjournal_volume
308pub_type
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