B cell translocation gene, a direct target of miR-142-5p, inhibits vascular smooth muscle cell proliferation by down-regulating cell cycle progression.

Abstract:

:Vascular smooth muscle cell (VSMC) proliferation plays a key role in neointimal hyperplasia and restenosis. Here we report the role of the microRNA miR-142-5p and its downstream target genes on the proliferation of cultured VSMCs. miR-142-5p promoted VSMC proliferation by down-regulating B cell translocation gene 3 (BTG3). We found that BTG3 inhibited the expression of cell cycle regulatory genes and cell growth. As shown by luciferase reporter assay, miR-142-5p bound directly to the 3'-untranslated region of BTG3. Overexpression of miR-142-5p induced expression of cell cycle regulatory genes. Thus, BTG3, a novel, direct target of miR-142-5p, negatively regulates VSMC proliferation.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Kee HJ,Park S,Kwon JS,Choe N,Ahn Y,Kook H,Jeong MH

doi

10.1016/j.febslet.2013.06.005

subject

Has Abstract

pub_date

2013-08-02 00:00:00

pages

2385-92

issue

15

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(13)00449-3

journal_volume

587

pub_type

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