Abstract:
:The inhibitory effects of various nitrogen-containing sugars on porcine kidney trehalase were studied. Validamycin A, validoxylamine A and MDL 25,637 were found to be potent, time-dependent inhibitors of the enzyme in vitro. The validoxylamine A-inhibited enzyme showed slow but reversible reactivation over time (t1/2 = 1.2 h). To our knowledge, this is the first report of time-dependent inhibition exhibited by either these particular aminosugars or a trehalase.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Salleh HM,Honek JFdoi
10.1016/0014-5793(90)80229-csubject
Has Abstractpub_date
1990-03-26 00:00:00pages
359-62issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(90)80229-Cjournal_volume
262pub_type
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