Abstract:
:The unfolded protein response (UPR)--the endoplasmic reticulum stress response--is found in various pathologies including ischemia-reperfusion injury (IRI). However, its role during IRI is still unclear. Here, by combining two different bioinformatical methods--a method based on ordinary differential equations (Time Series Network Inference) and an algebraic method (probabilistic polynomial dynamical systems)--we identified the IRE1α-XBP1 and the ATF6 pathways as the main UPR effectors involved in cell's adaptation to IRI. We validated these findings experimentally by assessing the impact of their knock-out and knock-down on cell survival during IRI.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Le Pape S,Dimitrova E,Hannaert P,Konovalov A,Volmer R,Ron D,Thuillier R,Hauet Tdoi
10.1016/j.febslet.2014.05.065subject
Has Abstractpub_date
2014-08-25 00:00:00pages
3062-7issue
17eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00490-6journal_volume
588pub_type
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