Abstract:
:Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Masaoka T,Suzuki H,Hosoda H,Ota T,Minegishi Y,Nagata H,Kangawa K,Ishii Hdoi
10.1016/s0014-5793(03)00306-5keywords:
subject
Has Abstractpub_date
2003-04-24 00:00:00pages
64-8issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579303003065journal_volume
541pub_type
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