Abstract:
:The activity of S-adenosylmethionine decarboxylase (AdoMetDC) in Crithidia fasciculata was shown to be correlated to the growth of the parasite. An increase in activity was observed during exponential growth. Inhibition of protein synthesis induced an extremely rapid decay of AdoMetDC activity. The half-life of the enzyme was estimated to be about 3 min, which is the shortest half-life ever recorded for an eukaryotic AdoMetDC. The reduction in AdoMetDC activity was correlated with a decrease in AdoMetDC protein content, demonstrating a rapid turnover of the enzyme. No polyamine-mediated feedback regulation of AdoMetDC was observed in the parasite.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nasizadeh S,Persson Ldoi
10.1016/s0014-5793(03)00986-4keywords:
subject
Has Abstractpub_date
2003-10-09 00:00:00pages
131-4issue
1-2eissn
0014-5793issn
1873-3468pii
S0014579303009864journal_volume
553pub_type
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