Abstract:
:Based on imino proton exchange catalysis, base-pair lifetimes and apparent dissociation constants are reported on the complexes formed by bisintercalation of echinomycin at the CpG steps of the d(ACGTATACGT)2 and d(ACGTTAACGT)2 duplexes. The lifetimes of the four central A x T base pairs between two echinomycin binding sites are much shorter than in the free duplexes. The destabilization of base pairs adjacent to the binding sites is propagated one additional base pair away from the binding site.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Park JY,Lee JH,Choi BSdoi
10.1016/s0014-5793(98)00366-4subject
Has Abstractpub_date
1998-04-24 00:00:00pages
325-30issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00366-4journal_volume
426pub_type
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