Abstract:
:The RhoGTPase Rac1 is activated in a polarised fashion and controls cell motility. We previously showed that Rac1 binds the PP2A inhibitor SET and recruits nuclear SET to the cytosol. We show that a SET mutant, lacking a nuclear localization signal, SET(ΔNLS), promotes cell spreading and motility. This was accompanied by an increase in the number and frequency of membrane ruffles. Pharmacological inhibition of PP2A did not mimic the effects of SET(ΔNLS), however, we found that expression of SET and SET(ΔNLS) increases the levels of the MAP kinases ERK1 and ERK2.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Lam BD,Anthony EC,Hordijk PLdoi
10.1016/j.febslet.2012.11.013subject
Has Abstractpub_date
2013-01-16 00:00:00pages
111-9issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00872-1journal_volume
587pub_type
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