Abstract:
:In exocrine acinar cells a variety of neurotransmitters (e.g. acetylcholine) stimulate phosphatidylinositol 4,5-bisphosphate hydrolysis elevating intracellular calcium to activate calcium-dependent membrane currents (outward K+ and inward Cl-). This study shows that in lacrimal acinar cells extracellular application of ATP is also associated with outward and inward current responses; these, however, are not the result of phosphoinositide metabolism. ATP directly activates receptor-operated cation channels which permit influx of Na+ and Ca+ (the inward current). The elevation in [Ca2+]i which results is sufficient to activate the outward K+ current. ATP thus promotes Ca+ influx in the absence of phosphoinositide metabolism.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sasaki T,Gallacher DVdoi
10.1016/0014-5793(90)80782-esubject
Has Abstractpub_date
1990-05-07 00:00:00pages
130-4issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(90)80782-Ejournal_volume
264pub_type
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