Abstract:
:Uncoupling protein 3 (UCP3) may reduce mitochondrial ROS production, and thereby protect against mitochondrial dysfunction in skeletal muscle. UCP3 has been suggested to specifically fulfill this role under high-fat conditions. Here we show that UCP3 knockout mice indeed have elevated mitochondrial ROS production after short-term (8 weeks) high-fat feeding. After 26 weeks of high-fat feeding, UCP3 knockout mice exhibited reduced mitochondrial function as measured ex vivo in isolated mitochondria. In conclusion, these data suggest that UCP3 may have a role in the protection of mitochondria against lipid-induced mitochondrial dysfunction, but only after long-term exposure to high-fat.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nabben M,Hoeks J,Moonen-Kornips E,van Beurden D,Briedé JJ,Hesselink MK,Glatz JF,Schrauwen Pdoi
10.1016/j.febslet.2011.11.012subject
Has Abstractpub_date
2011-12-15 00:00:00pages
4010-7issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(11)00837-4journal_volume
585pub_type
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