Abstract:
:The stomach form of alcohol dehydrogenase has been structurally evaluated by peptide analysis covering six separate regions of the rat enzyme. Overall, this new structure differs widely (32-40% residue differences) from the structures of three classes of alcohol dehydrogenase characterized before from the same species. Consequently, this novel enzyme constitutes a true fourth class of mammalian alcohol dehydrogenase. In particular, differences are extensive also towards class II, although enzymatic and physicochemical properties initially suggested overall similarities with class II. The new structure establishes the presence of one further alcohol dehydrogenase mammalian gene, extends the enzyme family derived from repeated gene duplications, and confirms tissue-specific expressions.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Parés X,Moreno A,Cederlund E,Höög JO,Jörnvall Jdoi
10.1016/0014-5793(90)80822-zsubject
Has Abstractpub_date
1990-12-17 00:00:00pages
115-8issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(90)80822-Zjournal_volume
277pub_type
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