Abstract:
:The low density lipoprotein receptor-related protein (LRP) is a multifunctional cell surface receptor highly expressed in human aortic smooth muscle cells. In the present study, we used the short interfering RNA (siRNA) technique to explore the role of LRP in smooth muscle cell migration. We identified an LRP-specific siRNA that selective silences LRP expression in human aortic smooth muscle cells. As a consequence, LRP-mediated ligand degradation was significantly reduced. More important, we found that platelet-derived growth factor-dependent cell migration was inhibited in cells transfected with LRP siRNA. These results demonstrate an important role of LRP in smooth muscle cell migration.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Li Y,Lu W,Bu Gdoi
10.1016/s0014-5793(03)01272-9keywords:
subject
Has Abstractpub_date
2003-12-04 00:00:00pages
346-50issue
2eissn
0014-5793issn
1873-3468pii
S0014579303012729journal_volume
555pub_type
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