Abstract:
:In the central nervous system, synaptic signal transduction depends on the regulation of neurotransmitter receptors by interacting proteins. Here, we searched for proteins interacting with two metabotropic glutamate receptor type 8 isoforms (mGlu8a and mGlu8b) and identified RanBPM. RanBPM is expressed in several brain regions, including the retina. There, RanBPM is restricted to the inner plexiform layer where it co-localizes with the mGlu8b isoform and processes of cholinergic amacrine cells expressing mGlu2 receptors. RanBPM interacts with mGlu2 and other group II and group III receptors, except mGlu6. Our data suggest that RanBPM might be associated with mGlu receptors at synaptic sites.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Seebahn A,Rose M,Enz Rdoi
10.1016/j.febslet.2008.06.010subject
Has Abstractpub_date
2008-07-09 00:00:00pages
2453-7issue
16eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00499-7journal_volume
582pub_type
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