Crystallographic and solution structure of the N-terminal domain of the Rel protein from Mycobacterium tuberculosis.

abstract：:Various vertebrates use ultraviolet (UV) vision for such basic behaviors as mating, foraging, and predation. We have successfully interchanged the color-sensitivities of the mouse UV pigment and the human blue pigment by introducing forward and reverse mutations at five sites. This unveils for the first time the gener...

journal_title：FEBS letters

authors： Yokoyama S,Shi Y

更新日期：2000-12-08 00:00:00

abstract：:We have explored the mechanisms involved in the facilitation of glutamate release mediated by the activation of kainate receptors (KARs) in the cortex using isolated nerve terminals (synaptosomes). Kainate (KA) produced an increase on glutamate release at 100 μM. The effect of KA was antagonized by NBQX (with AMPA rec...

journal_title：FEBS letters

authors： Rodríguez-Moreno A,Sihra TS

更新日期：2013-03-18 00:00:00

abstract：:Cathelicidins are a group of myeloid antimicrobial peptide precursors found in a variety of mammalian species. Transcripts of this family show a highly conserved 5' region corresponding to the 5' untranslated region, signal peptide and propiece, and diverse 3' regions encoding structurally varied C-terminal sequences ...

journal_title：FEBS letters

authors： Scocchi M,Wang S,Zanetti M

更新日期：1997-11-17 00:00:00

abstract：:In human pancreatic islets an increase in the glucose concentration from 3 to 20 mM raised the free cytoplasmic Ca2+ concentration [( Ca2+]i), an effect being reversible upon withdrawal of the sugar. Depolarization with a high concentration of K+ or the sulphonylurea tolbutamide also raised [Ca2+]i. Addition of extrac...

journal_title：FEBS letters

authors： Kindmark H,Köhler M,Nilsson T,Arkhammar P,Wiechel KL,Rorsman P,Efendić S,Berggren PO

更新日期：1991-10-21 00:00:00

abstract：:We have previously shown that Rap1 as well as its guanine nucleotide exchange factor Epac1 increases cell-cell junction formation. Here, we show that activation of Epac1 with the exchange protein directly activated by cAMP (Epac)-specific cAMP analog 8CPT-2'O-Me-cAMP (007) resulted in a tightening of the junctions and...

journal_title：FEBS letters

authors： Kooistra MR,Corada M,Dejana E,Bos JL

更新日期：2005-09-12 00:00:00

abstract：:Cellulysin, a crude cellulase from the plant parasitic fungus Trichoderma viride, induces the biosynthesis of volatiles in higher plants (Nicotiana plumbaginifolia, Phaseolus lunatus, and Zea mays) when applied to cut petioles by the transpiration stream. The pattern of the emitted volatiles largely resembles that fro...

journal_title：FEBS letters

authors： Piel J,Atzorn R,Gäbler R,Kühnemann F,Boland W

更新日期：1997-10-20 00:00:00

abstract：:In fibrous connective tissues, fibroblasts are organized into syncytia, cellular networks that enable matrix remodeling and that are interconnected by intercellular adherens junctions (AJs). The AJs of fibroblasts are mediated by N-cadherin, a broadly expressed classical cadherin that is critically involved in develop...

journal_title：FEBS letters

authors： El Sayegh TY,Kapus A,McCulloch CA

更新日期：2007-01-23 00:00:00

abstract：:Treatment of the myeloid cell lines, U-937 or HL-60, with 10 nM of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), for 24 h increased the rate of incorporation of [3H]glycerol into total chloroform extracts. A proportionally greater labeling of the non-polar lipid (NL) fraction compared to the polar, ph...

journal_title：FEBS letters

authors： Ponzoni M,DeBell KE,Hoffman T,Bonvini E

更新日期：1990-12-10 00:00:00

abstract：:Analysis of the beta-ketoacyl-ACP synthase (KAS) encoded by the fabF gene of Escherichia coli has been hampered by a reported instability of the cloned gene. Here we describe biochemical characterization of purified, active protein from the recombinant fabF gene. This enzyme has the properties ascribed to KAS II and n...

journal_title：FEBS letters

authors： Edwards P,Nelsen JS,Metz JG,Dehesh K

更新日期：1997-01-27 00:00:00

abstract：:A novel member of the human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase gene family, designated GalNAc-T7, was cloned and expressed. GalNAc-T7 exhibited different properties compared to other characterized members of this gene family, in showing apparent exclusive specificity for partial...

journal_title：FEBS letters

authors： Bennett EP,Hassan H,Hollingsworth MA,Clausen H

更新日期：1999-10-29 00:00:00

abstract：:Accurate cDNA data is useful to validate gene structures in a genome. We sequenced 35189 expressed sequence tags (ESTs) obtained from the highly destructive rice blast fungus, Magnaporthe grisea. Our custom-made computational programs mapped these ESTs on the M. grisea genome sequence, and reconstructed gene structure...

journal_title：FEBS letters

authors： Numa H,Nishimura M,Tanaka T,Kanamori H,Yang CC,Matsumoto T,Nagamura Y,Itoh T

更新日期：2009-02-18 00:00:00

abstract：:In the filamentous fungus Neurospora, the production of dsRNA can elicit a dsRNA-induced transcriptional response similar to the interferon response in vertebrates. However, how fungi sense the expression of dsRNA and activate gene expression is unknown. In this study, we established a dsRNA response reporter system i...

journal_title：FEBS letters

authors： Li X,Shen Y,Sun J,Wang B,He Q

更新日期：2011-03-23 00:00:00

abstract：:Perturbation of the aerobic steady-state in a chemostat culture of the ethanol-producing bacterium Zymomonas mobilis with a small pulse of ethanol causes a burst of ethanol oxidation, although the reactant ratio of the alcohol dehydrogenase (ADH) reaction ([NADH][acetaldehyde][H(+)])/([ethanol][NAD(+)]) remains above ...

journal_title：FEBS letters

authors： Kalnenieks U,Galinina N,Toma MM,Pickford JL,Rutkis R,Poole RK

更新日期：2006-09-18 00:00:00

abstract：:Tyrosine O-sulfation is one of the post-translational modification processes that occur to membrane proteins and secreted proteins in eukaryotes. Tyrosylprotein sulfotransferase (TPST) is responsible for this modification, and in this report, we describe the expression pattern and the biological role of TPST-A in the ...

journal_title：FEBS letters

authors： Kim TH,Hwang SB,Jeong PY,Lee J,Cho JW

更新日期：2005-01-03 00:00:00

abstract：:The ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar endo- and xenobiotics in the human body, especially in the tissue barriers and the metabolizing or secreting organs. The human ABCG2 gene harbors a high number of polymorphisms and mutations, which may significantly modulate i...

journal_title：FEBS letters

authors： Sarkadi B,Homolya L,Hegedűs T

更新日期：2020-10-04 00:00:00

abstract：:The ADP(Mg2+)-deactivated oligomycin-sensitive F1-F0 ATPase of coupled submitochondrial particles treated with the substoichiometric amount of oligomycin was studied to test whether ATP synthesis and hydrolysis proceed in either direction through the same intermediates. The initial rates of ATP hydrolysis, oxidative p...

journal_title：FEBS letters

authors： Syroeshkin AV,Vasilyeva EA,Vinogradov AD

更新日期：1995-06-05 00:00:00

abstract：:The c-Jun N-terminal kinase (JNK) signalling pathway has an established role in cellular stress signalling, cell survival and tumorigenesis. Here, we demonstrate that inhibition of JNK signalling results in partial delocalization of the RNA helicase DDX21 from the nucleolus to the nucleoplasm, increased nucleolar mobi...

journal_title：FEBS letters

authors： Mialon A,Thastrup J,Kallunki T,Mannermaa L,Westermarck J,Holmström TH

更新日期：2008-09-03 00:00:00

abstract：:The complete amino acid sequence of porcine muscarinic acetylcholine receptor III has been deduced by cloning and sequencing the genomic DNA. The antagonist binding properties of muscarinic acetylcholine receptor III expressed from the cloned DNA in Xenopus oocytes correspond most closely to those of the pharmacologic...

journal_title：FEBS letters

authors： Akiba I,Kubo T,Maeda A,Bujo H,Nakai J,Mishina M,Numa S

更新日期：1988-08-01 00:00:00

abstract：:Electrospray/mass spectrometry (ES/MS) was extensively used to obtain information on disulphide-containing intermediates formed during refolding of bovine pancreatic ribonuclease A. The analysis showed the existence of an equilibrated population of disulphide bonded intermediates, and indicates that intermediates cont...

journal_title：FEBS letters

authors： Torella C,Ruoppolo M,Marino G,Pucci P

更新日期：1994-10-03 00:00:00

abstract：:Saccharomyces bayanus var. uvarum investigated here is the species closest to Saccharomyces cerevisiae. Random sequence tags (RSTs) allowed us to identify homologues to 2789 open reading frames (ORFs) in S. cerevisiae, ORFs duplicated in S. uvarum but not in S. cerevisiae, centromeres, tRNAs, homologues of Ty1/2 and T...

journal_title：FEBS letters

authors： Bon E,Neuvéglise C,Casaregola S,Artiguenave F,Wincker P,Aigle M,Durrens P

更新日期：2000-12-22 00:00:00

abstract：:The fraction of polyclonal caldesmon antibodies cross-reacting with rabbit skeletal troponin T are shown to compete with smooth muscle tropomyosin for caldesmon and troponin T, as revealed by ELISA method. The epitope recognized by these antibodies was also found in Mr 77 kDa non-muscle caldesmon. These results provid...

journal_title：FEBS letters

authors： Birukov KG,Shirinsky VP,Vorotnikov AV,Gusev NB

更新日期：1990-03-26 00:00:00

abstract：:SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in ...

journal_title：FEBS letters

authors： Law PY,Liu YM,Geng H,Kwan KH,Waye MM,Ho YY

更新日期：2006-06-26 00:00:00

abstract：:Effects of sulfatide and its precursor galactosylceramide (gal-cer) on the kinetics of production of cytokines were studied. In human mononuclear leucocytes, gal-cer but not sulfatide induced significantly increased amounts of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF) mRNA. In phytohemagglutinin-sti...

journal_title：FEBS letters

authors： Bovin LF,Fredman P,Månsson JE,Buschard K,Bendtzen K

更新日期：1999-07-23 00:00:00

abstract：:We have previously identified an ESE in NF1 exon 37 whose disruption by the pathological mutation c.6792C>G caused aberrant splicing. We now investigate the RNA-protein complexes affected by the c.6792C>G mutation observing that this concurrently decreases the affinity for the positive splicing factor YB-1 and increas...

journal_title：FEBS letters

authors： Skoko N,Baralle M,Buratti E,Baralle FE

更新日期：2008-06-25 00:00:00

abstract：:A rat urokinase receptor (uPAR) cDNA fragment was amplified by RT-PCR from RNA of the rat osteoblastic cell line CFK-1. Using this DNA species as a hybridization probe two rat uPAR cDNAs were isolated from a CFK-1 cDNA library. These two cDNAs encode an identical uPAR protein except for a single base mutation which re...

journal_title：FEBS letters

authors： Rabbani SA,Rajwans N,Achbarou A,Murthy KK,Goltzman D

更新日期：1994-01-24 00:00:00

abstract：:Stimulation of mast cells through their high affinity IgE receptor (FcεRI) leads to the secretion of pre- and neoformed soluble mediators through vesicular carriers. This process is highly regulated in order to adapt the secretion of these potentially dangerous factors to the physiological needs. This regulation requi...

journal_title：FEBS letters

authors： Benhamou M,Blank U

更新日期：2010-12-15 00:00:00

abstract：:1,2-Didecanoylglycerol (diC10) is taken up by human platelets and sequentially converted to 1,2-didecanoylphosphatidic acid (PA10) and 1,2-didecanoylphosphatidylinositol (PI10). Agents that increase cyclic AMP in platelets, such as prostacyclin and forskolin, sequentially convert diC10 to PA10 and PI10. They decrease ...

journal_title：FEBS letters

authors： Lapetina EG

更新日期：1986-01-20 00:00:00

abstract：:Spectrin repeats are three-helix bundle structures which occur in a large number of diverse proteins, either as single copies or in tandem arrangements of multiple repeats. They can serve structural purposes, by coordination of cytoskeletal interactions with high spatial precision, as well as a 'switchboard' for inter...

journal_title：FEBS letters

authors： Djinovic-Carugo K,Gautel M,Ylänne J,Young P

更新日期：2002-02-20 00:00:00

abstract：:Only one copy of the cell adhesion molecule L1 gene is present in the mouse genome, and only one mRNA of 6 kilobases (kb) is expressed in mouse brain [1987, Neurosci. Lett. 82, 89-94]. We have constructed 5 synthetic oligonucleotide probes covering different parts of the published mouse L1 cDNA sequence. Using these p...

journal_title：FEBS letters

authors： Gaardsvoll H,Andersson AM,Bock E

更新日期：1991-12-02 00:00:00

abstract：:Communication between endothelial and smooth muscle cells (SMCs) contributes to atherosclerosis induced by atherogenic factors, such as oxide LDL. Asymmetric dimethylarginine (ADMA), a newly found cardiovascular risk factor, accumulates in the culture medium of oxide LDL (oxLDL)-treated endothelial cells and positivel...

journal_title：FEBS letters

authors： Sun L,Zhang T,Yu X,Xin W,Lan X,Zhang D,Huang C,Du G

更新日期：2011-09-02 00:00:00