Abstract:
:A variety of plant tissues contain an uncoupling mitochondrial protein (PUMP), recently described and characterized by our group. In this study we show that the inhibition of PUMP activity in potato tuber mitochondria significantly increases mitochondrial H2O2 generation, while PUMP substrates, such as linoleic acid, reduce mitochondrial H2O2 generation. This H2O2 generation occurred mainly by the dismutation of superoxide radicals formed through monoelectronic reduction of O2 by semiquinone forms of coenzyme Q. The results presented suggest that protection against mitochondrial oxidative stress may be a physiological role of PUMP.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kowaltowski AJ,Costa AD,Vercesi AEdoi
10.1016/s0014-5793(98)00231-2subject
Has Abstractpub_date
1998-03-27 00:00:00pages
213-6issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00231-2journal_volume
425pub_type
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