Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells.

Abstract:

:The effect of persistent measles virus infection on c-fos protooncogene and protein kinase C (PKC-I) gene expression in a murine neuroblastoma cell line was studied. Overexpression of c-fos protooncogene by infected NS20Y/MS cells was detected when compared with uninfected NS20Y cells. The level of PKC-I-specific mRNA was increased in infected NS20Y/MS cells. In addition, the level of total PKC activity in these cells was also enhanced. We conclude that persistent measles virus infection can alter both protooncogene expression and signal transduction in cells of neuronal origin.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Wolfson M,Katorza A,Segal S,Rager-Zisman B

doi

10.1016/0014-5793(89)80757-4

subject

Has Abstract

pub_date

1989-07-03 00:00:00

pages

367-70

issue

2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(89)80757-4

journal_volume

250

pub_type

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