Abstract:
:The effect of persistent measles virus infection on c-fos protooncogene and protein kinase C (PKC-I) gene expression in a murine neuroblastoma cell line was studied. Overexpression of c-fos protooncogene by infected NS20Y/MS cells was detected when compared with uninfected NS20Y cells. The level of PKC-I-specific mRNA was increased in infected NS20Y/MS cells. In addition, the level of total PKC activity in these cells was also enhanced. We conclude that persistent measles virus infection can alter both protooncogene expression and signal transduction in cells of neuronal origin.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wolfson M,Katorza A,Segal S,Rager-Zisman Bdoi
10.1016/0014-5793(89)80757-4subject
Has Abstractpub_date
1989-07-03 00:00:00pages
367-70issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(89)80757-4journal_volume
250pub_type
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