Abstract:
:Nitric oxide, as well as being a major regulator of vascular reactivity, has been shown to be one of the mediators of cytotoxicity in macrophages. This cytotoxic effect seems to be due to the interaction between nitric oxide and oxygen-related free radicals. This study shows that, in vitro, nitric oxide reacts with hydrogen peroxide to release large amounts of chemiluminescence with the characteristics of the highly cytotoxic species, singlet oxygen. This is supported by the observation that when nitric oxide was added to a superoxide generating system, catalase inhibited the production of singlet oxygen while superoxide dismutase enhanced it.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Noronha-Dutra AA,Epperlein MM,Woolf Ndoi
10.1016/0014-5793(93)80621-zsubject
Has Abstractpub_date
1993-04-19 00:00:00pages
59-62issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(93)80621-Zjournal_volume
321pub_type
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