Abstract:
:All eukaryotic cells enclose their genome within a dedicated, membrane-bound organelle termed the nucleus, which functions to partition gene transcription from sites of protein translation in the cytoplasm. Despite a great deal of research effort, basic questions about chromosome structure and gene expression mechanisms remain to be answered, including the relationship between the spatial organization of the genome and the transcription machinery. Powerful in vivo approaches are allowing researchers to test established in vitro concepts within the dynamic cellular environment, while genome-wide screens have enabled rapid high throughput analyses of both structural and functional parameters. In several cases, as highlighted here, this has turned up surprising results and has forced a re-evaluation of models for nuclear structure and gene regulation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Trinkle-Mulcahy L,Lamond AIdoi
10.1016/j.febslet.2008.04.029subject
Has Abstractpub_date
2008-06-18 00:00:00pages
1960-70issue
14eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00357-8journal_volume
582pub_type
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