Abstract:
:Mesothelial cells, which cover the surface of visceral organs and serous cavities in mammals, play a crucial role in preventing adhesion. We previously reported that primary mesothelial progenitor cells (MPCs) can not only prevent postoperative adhesion but also promote liver regeneration after hepatectomy. Induced pluripotent stem cells (iPSCs) have the potential to be used for regenerative medicine. Here, we have established a differentiation protocol for mouse iPSC-derived MPCs (miMPCs) via the exposure to defined factors, as well as purification using MPC-specific cell surface antigens. Furthermore, the miMPCs had the ability to suppress postoperative adhesion and facilitate liver regeneration. This is the first report highlighting the generation of functional miMPCs, which may offer potential for de novo cell therapy.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Inagaki NF,Inagaki FF,Kokudo N,Miyajima Adoi
10.1002/1873-3468.13325subject
Has Abstractpub_date
2019-02-01 00:00:00pages
386-394issue
4eissn
0014-5793issn
1873-3468journal_volume
593pub_type
杂志文章相关文献
FEBS LETTERS文献大全abstract::Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 plays a pivotal role in mediating the nuclear export of KSHV intronless transcripts. We demonstrate that ORF57 localises and dynamically trafficks through the nucleolus. To assess if nucleolar shuttling of ORF57 is important for the export of intronless viral mRNA, ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2009.10.040
更新日期:2009-11-19 00:00:00
abstract::Galanin mediates diverse physiological functions in digestive, endocrine, and central nervous systems through G-protein-coupled receptors. Two galanin receptors have been cloned but the gene structures are unknown. We report genomic and cDNA cloning of the mouse GalR1 galanin receptor and demonstrate that the coding s...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(97)00695-9
更新日期:1997-07-14 00:00:00
abstract::The mechanisms controlling fat depot-specific metabolism are poorly understood. During starvation of mice, downregulation of lipogenic genes, suppression of fatty acid synthesis, and increases in lipid oxidation were all more pronounced in epididymal than in subcutaneous fat. In epididymal fat, relatively strong upreg...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2005.09.078
更新日期:2005-11-07 00:00:00
abstract::Inborn errors of the urea cycle, liver malfunction and drug-induced hepatotoxicity are causes of life-threatening encephalopathies arising from hyperammonemia. L-Carnitine prevented entirely ammonia toxicity in mice when injected intraperitoneally 30 min before a lethal dose of ammonium acetate. Survival depends on th...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(84)80106-4
更新日期:1984-01-30 00:00:00
abstract::Expression of the leptin receptor gene has been examined in mouse hypothalamus and other brain regions by in situ hybridization. With a probe recognizing all the known splice variants, receptor mRNA was evident in several brain regions (cortex, hippocampus, thalamus), with strong expression in the hypothalamus (arcuat...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(96)00473-5
更新日期:1996-06-03 00:00:00
abstract::It was believed that there was no natural suppressor tRNA in Escherichia coli, however, it has been suggested that selC, relating to the synthesis of formate dehydrogenase of a selenoprotein [(1988) Nature 331, 723-725], codes for tRNA, even though the presence of tRNA has not yet been demonstrated. We detected the pr...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(89)81367-5
更新日期:1989-04-24 00:00:00
abstract::Human cystatin C (HCC) is a low molecular weight member of the cystatin family (type2). HCC consists of 120 amino acids. Normally it is an inhibitor of cysteine proteases, but in pathological conditions it forms amyloid fibrils in brain arteries of young adults. An 'aggregation-prone' pentapeptide ((47)LQVVR(51)) was ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2014.11.041
更新日期:2015-01-02 00:00:00
abstract::Lateral mobility of the vasopressin renal-type V2-receptor was investigated in LLC-PK1 porcine epithelial cells using the technique of fluorescence microphotolysis (photobleaching) and a rhodamine-labelled vasopressin analogue. At various times after ligand addition, cells were analyzed for both receptor lateral mobil...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(90)81368-x
更新日期:1990-11-12 00:00:00
abstract::We report the identification of bovine miRNAs by cloning small RNAs from adipose tissue and the mammary gland. Fifty-nine distinct miRNAs were identified, five of them were not homologous to known mammalian miRNAs, and many of them had 3' and/or 5' end variants. Ribonuclease protection assays indicated that miR-23a an...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2007.01.081
更新日期:2007-03-06 00:00:00
abstract::The use of tobacco plants as a novel expression system for the production of human homotrimeric collagen I is presented in this report. Constructs were engineered from cDNA encoding the human proalpha1(I) chain to generate transgenic tobacco plants expressing collagen I. The recombinant proalpha1(I) chains were expres...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(00)01259-x
更新日期:2000-03-03 00:00:00
abstract::In higher eukaryotes, nine aminoacyl-tRNA synthetases form a multienzyme complex also comprising the three auxiliary proteins p18, p38 and p43, of apparent molecular masses of 18, 38 and 43 kDa. The function of these proteins, invariably found associated to the synthetase components of the complex, is unknown. In orde...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(96)01005-8
更新日期:1996-10-14 00:00:00
abstract::Regulatory protein kinases are involved in various cellular processes such as proliferation, differentiation, and apoptosis. Using cDNA differential display, we identified MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, C...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2004.07.070
更新日期:2004-08-27 00:00:00
abstract::A fusion gene was constructed consisting of heat labile enterotoxin chain B (LTB) of E. coli genetically linked at its C-terminus to the beta-subunit of human chorionic gonadotropin in translational fusion, under the control of tac promoter and LTB signal sequence. Expression of the fusion gene (about 5 microgram/ml) ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(96)00428-0
更新日期:1996-05-27 00:00:00
abstract::Vitronectin is the carrier protein of plasminogen activator inhibitor 1 (PAI-1). We used a well-characterized panel of anti-human PAI-1 monoclonal antibodies (MoAbs) to localize the vitronectin-binding site on PAI-1. By employing a direct vitronectin/PAI-1 binding assay and two vitronectin-dependent inhibition assays,...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)00990-2
更新日期:1994-10-03 00:00:00
abstract::In the past two decades, the ATP-binding cassette (ABC) transporters' field has undergone a structural revolution. The importance of structural biology to the development of the field of ABC transporters cannot be overstated, as the ensemble of structures not only revealed the architecture of ABC transporters but also...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13966
更新日期:2020-10-24 00:00:00
abstract::Lys601 in NADPH-cytochrome P-450 reductase is modified by reductive alkylation with pyridoxal 5'-phosphate (pyridoxylation). Lys601 is protected against modification by the cosubstrate NADP(H). ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(90)80125-3
更新日期:1990-01-29 00:00:00
abstract::Bovine tryptophanyl-tRNA synthetase (TrpRS, E.C.6.1.1.2) is unable to catalyze in vitro formation of Ap4A in contrast to some other aminoacyl-tRNA synthetases. However, in the presence of L-tryptophan, ATP-Mg2+ and ADP the enzyme catalyzes the Ap3A synthesis via adenylate intermediate. Ap3A (not Ap4A) may serve as a s...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)00764-0
更新日期:1994-08-22 00:00:00
abstract::The number of proteins found in body fluids and at cell surfaces, which are known to display carbohydrate-binding properties, continues to increase rapidly. In these proteins, in addition to a domain associated with lectin properties, one or more, non-lectin domains are present. It is possible that binding of sugar re...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/0014-5793(89)80689-1
更新日期:1989-06-19 00:00:00
abstract::Coeliac disease is a chronic enteropathy caused by the ingestion of wheat gliadin and other cereal prolamines derived from rye and barley. In the present work, we investigated the mechanisms underlying altered barrier function properties exerted by gliadin-derived peptides in human Caco-2 intestinal epithelial cells. ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2005.07.066
更新日期:2005-08-29 00:00:00
abstract::The amyloid precursor protein (APP) is proteolytically processed by β- and γ-secretases to release amyloid-β peptide (Aβ), the main component found in senile plaques of Alzheimer's disease (AD) patient brains. Alternatively, APP can be cleaved within the Aβ sequence by α-secretase, thus precluding the generation of Aβ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2011.05.048
更新日期:2011-07-21 00:00:00
abstract::Osteoblastic cells have been shown to be involved in osteoclast formation through cell to cell contacts. This study was designed to examine the possible function of vascular cell adhesion molecule 1 (VCAM-1) during osteoclastogenesis. As a source for stromal cells we used the recently established mouse bone marrow str...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(96)01495-0
更新日期:1997-01-27 00:00:00
abstract::As a SNARE binding protein, tomosyn has been reported to negatively regulate synaptic exocytosis via arresting syntaxin-1 and SNAP-25 into a nonfusogenic product that precludes synaptobrevin-2 entry, raising the question how the assembly of the SNARE complex is achieved. Here, we have investigated new functions of tom...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.13018
更新日期:2018-04-01 00:00:00
abstract::Caloric restriction (CR) is known to promote longevity in various species. Sirtuin-mediated deacetylation has been shown to be related to the promotion of longevity in some species. Here, we show that CR of rats led to an increase in the level of Werner syndrome protein (WRN), a recognized DNA repair protein. In addit...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2008.06.031
更新日期:2008-07-23 00:00:00
abstract::Elongation factors EF-G and EF-Tu are structural homologues and share near-identical binding sites on the ribosome, which encompass the GTPase-associated centre (GAC) and the sarcin-ricin loop (SRL). The SRL is fixed structure in the ribosome and contacts elongation factors in the vicinity of their GTP-binding site. I...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/j.febslet.2005.09.010
更新日期:2005-10-24 00:00:00
abstract::Data are presented on the formation of a linoleic acid oxygenation product under basal conditions by guinea pig alveolar macrophages (AM). Under non-stimulated conditions 20 X 10(6) AM released about 1 nmol 9-hydroxylinoleic acid (9-HODE) during a 15 min incubation. Furthermore, AM released more than 2 nmol 12-hydroxy...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(86)81121-8
更新日期:1986-12-15 00:00:00
abstract::The glycogen-binding (G) subunit of protein phosphatase-1G is phosphorylated stoichiometrically by glycogen synthase kinase-3 (GSK3), and with a greater catalytic efficiency than glycogen synthase, but only after prior phosphorylation by cyclic AMP-dependent protein kinase (A-kinase) at site 1. The residues phosphoryl...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(89)80433-8
更新日期:1989-05-08 00:00:00
abstract::The binding of phosphatidylinositol(4,5)-bisphosphate (PI(4,5)P(2)) to profilin at a region distinct from the actin interaction surface is demonstrated by experiments with covalently cross-linked profilin:beta-actin. The result is in agreement with observations made with several mutant profilins and provides strong ev...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)02913-7
更新日期:2002-07-03 00:00:00
abstract::Blood reprogramming, in which induced pluripotent stem cells (iPSCs) are derived from haematopoietic lineages, has rapidly advanced over the past decade. Since the first report using human blood, haematopoietic cell types from various sources, such as the peripheral bone marrow and cord blood, have been successfully r...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13659
更新日期:2019-12-01 00:00:00
abstract::This paper reviews our present knowledge of sphingomyelinases as enzymes, and as enzymes acting on a membrane constituent lipid, sphingomyelin. Six types of sphingomyelinases are considered, namely acidic, secretory, Mg(2+)-dependent neutral, Mg(2+)-independent neutral, alkaline, and bacterial enzymes with both phosph...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/s0014-5793(02)03482-8
更新日期:2002-10-30 00:00:00
abstract::Macrophages contain arginase and an inducible NO synthase, demonstrated by using L-arginine, the common substrate, for production of both nitric oxide and urea. Arginase was inhibited by nitrite, the stable end product of NO. This inhibition was non-competitive, and could not be explained by the reaction of nitrite wi...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(96)00659-x
更新日期:1996-07-22 00:00:00