Abstract:
:Sialic acids comprise a family of terminal sugars essential for a variety of biological recognition systems. UDP-N-acetylglucosamine 2-epimerase catalyzes the first step of their biosynthesis. Periodate-oxidized UDP-N-acetylglucosamine, namely 2',3'-dialdehydo-UDP-alpha-D-N-acetylglucosamine, was found to be an effective inhibitor of this enzyme, compared with the periodate oxidation products of compounds such as UDP, uridine or methyl riboside. It bound covalently to amino acids in the active site causing an irreversible inhibition. This compound may therefore represent a basis for the synthesis of potent inhibitors of UDP-N-acetylglucosamine 2-epimerase and, as a consequence, of the biosynthesis of sialic acids.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Blume A,Chen H,Reutter W,Schmidt RR,Hinderlich Sdoi
10.1016/s0014-5793(02)02856-9keywords:
subject
Has Abstractpub_date
2002-06-19 00:00:00pages
127-32issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579302028569journal_volume
521pub_type
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