Abstract:
:Chaperone-mediated autophagy (CMA) is a lysosomal pathway that participates in the degradation of cytosolic proteins. CMA is activated by starvation and in response to stressors that result in protein damage. The selectivity intrinsic to CMA allows for removal of damaged proteins without disturbing nearby functional ones. CMA works in a coordinated manner with other autophagic pathways, which can compensate for each other. Interest in CMA has recently grown because of the connections established between this autophagic pathway and human pathologies. Here we review the unique properties of CMA compared to other autophagic pathways and its relevance in health and disease.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kon M,Cuervo AMdoi
10.1016/j.febslet.2009.12.025subject
Has Abstractpub_date
2010-04-02 00:00:00pages
1399-404issue
7eissn
0014-5793issn
1873-3468pii
S0014-5793(09)01071-0journal_volume
584pub_type
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