Abstract:
:Viperin is a radical SAM enzyme that possesses antiviral properties against a broad range of enveloped viruses. Here, we describe the activity of human viperin with two molecules of the mevalonate pathway, geranyl pyrophosphate, and farnesyl pyrophosphate, involved in cholesterol biosynthesis. We postulate that the radical modification of these two molecules by viperin might lead to defects in cholesterol synthesis, thereby affecting the composition of lipid rafts and subsequent enveloped virus budding.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mikulecky P,Andreeva E,Amara P,Weissenhorn W,Nicolet Y,Macheboeuf Pdoi
10.1002/1873-3468.12941subject
Has Abstractpub_date
2018-01-01 00:00:00pages
199-208issue
2eissn
0014-5793issn
1873-3468journal_volume
592pub_type
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