Enterohemolysin operon of Shiga toxin-producing Escherichia coli: a virulence function of inflammatory cytokine production from human monocytes.

Abstract:

:Shiga toxin-producing Escherichia coli (STEC) is associated with hemolytic uremic syndrome (HUS). Although most clinical isolates of STEC produce hemolysin (called enterohemolysin), the precise role of enterohemolysin in the pathogenesis of STEC infections is unknown. Here we demonstrated that E. coli carrying the cloned enterohemolysin operon (hlyC, A, B, D genes) from an STEC human strain induced the production of interleukin-1beta (IL-1beta) through its mRNA expression but not tumor necrosis factor-alpha from human monocytes. No IL-1beta release was observed with an enterohemolysin (HlyA)-negative, isogenic E. coli strain carrying a mutation in the hlyA gene. The data suggest that enterohemolysin, a pore-forming toxin, induces the production of IL-1beta, which is one of serum risk markers for HUS.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Taneike I,Zhang HM,Wakisaka-Saito N,Yamamoto T

doi

10.1016/s0014-5793(02)03027-2

keywords:

subject

Has Abstract

pub_date

2002-07-31 00:00:00

pages

219-24

issue

1-3

eissn

0014-5793

issn

1873-3468

pii

S0014579302030272

journal_volume

524

pub_type

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