Abstract:
:Human monoclonal antibodies often display limited thermodynamic and colloidal stabilities. This behavior hinders their production, and places limitations on the development of novel formulation conditions and therapeutic applications. Antibodies are highly diverse molecules, with much of the sequence variation observed within variable domain families and, in particular, their complementarity determining regions. This has complicated the development of comprehensive strategies for the stability engineering of the human antibody repertoire. Here we provide an overview of the field, and discuss recent advances in the development of robust and aggregation resistant antibody therapeutics.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rouet R,Lowe D,Christ Ddoi
10.1016/j.febslet.2013.11.029subject
Has Abstractpub_date
2014-01-21 00:00:00pages
269-77issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00873-9journal_volume
588pub_type
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