Abstract:
:Early B-cell factor 1 (Ebf1) is a transcription factor whose inactivation in all cells results in high bone mass because of an increase in bone formation. This observation suggests Ebf1 may be an inhibitor of osteoblast differentiation. To test this contention, we analyzed Ebf1 pattern of expression and function in osteoblasts ex vivo and in vivo through osteoblast-specific inactivation in the mouse. We show here that in vivo deletion of Ebf1 in osteoblast progenitors does not affect osteoblast differentiation or bone formation accrual post-natally. These observations indicate that the phenotype described in Ebf1(-/)(-) mice is not osteoblast-autonomous.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Zee T,Boller S,Györy I,Makinistoglu MP,Tuckermann JP,Grosschedl R,Karsenty Gdoi
10.1016/j.febslet.2013.01.049subject
Has Abstractpub_date
2013-03-18 00:00:00pages
711-6issue
6eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00094-Xjournal_volume
587pub_type
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