Abstract:
:Uptake of cholesterol by isolated rat hepatocytes in a serum-free medium was remarkably enhanced by dispersion with several kinds of phosphatidylcholine. Of the various phosphatidylcholines tested, dilinoylphosphatidylcholine had the strongest accelerating effect, while dipalmitoylphosphatidylcholine was the weakest. The abilities to accelerate cholesterol uptake were in proportion to the content of unsaturated fatty acid in the phosphatidylcholine used. It was confirmed by electron microscopy that there is no relation between the size of the cholesterol-phosphatidylcholine complex and uptake. These data suggest that recognition of unsaturated fatty acids in phosphatidylcholine by isolated cells enhances uptake of cholesterol.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nagamura Y,Sasaki K,Ito M,Saito K,Ogitsu N,Ishiguro Idoi
10.1016/0014-5793(86)81443-0subject
Has Abstractpub_date
1986-07-14 00:00:00pages
91-4issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(86)81443-0journal_volume
203pub_type
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