Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation.

abstract：:The essential role of Factor VIII:C (FVIII:C, anti-hemophilia factor A) as a cofactor for Factor IXa-dependent activation of Factor X has been established. In this paper, we describe that capillary endothelial cells from bovine adrenal medulla express active FVIII:C gene. Accumulation of FVIII:C in conditioned media f...

journal_title：FEBS letters

authors： Banerjee DK,Tavárez JJ,Oliveira CM

更新日期：1992-07-13 00:00:00

abstract：:Abstract Hyperhomocysteinemia has recently been identified as an important risk factor for Alzheimer's disease (AD). One of the potential mechanisms underlying harmful effects of homocysteine (Hcy) is site-specific acylation of proteins at lysine residues by homocysteine thiolactone (HCTL). The accumulation of amyloid...

journal_title：FEBS letters

authors： Khodadadi S,Riazi GH,Ahmadian S,Hoveizi E,Karima O,Aryapour H

更新日期：2012-01-20 00:00:00

abstract：:Dark-adapted isolated spinach chloroplasts and leaves, unlike sub-chloroplast fractions, are capable of emitting ultraweak light spontaneously (50-125 counts/s per cm2). The emission of leaves is due to two processes with activation energies of 97 and 25 kJ/mol while in isolated chloroplasts, it is the result of a sin...

journal_title：FEBS letters

authors： Hideg E,Kobayashi M,Inaba H

更新日期：1990-11-26 00:00:00

abstract：:Antithrombin III Hamilton is a structural variant of antithrombin III (AT-III) with normal heparin affinity but impaired serine protease inhibitory activity. The molecular defect of AT-III-Hamilton is a substitution of threonine for alanine at amino acid residue 382. Recently it has been shown that both plasma-derived...

journal_title：FEBS letters

authors： Austin RC,Rachubinski RA,Blajchman MA

更新日期：1991-03-25 00:00:00

abstract：:The relationship among the real-time trafficking of lung metastatic B16BL6 cells, metastatic potential, and the injected number of the cells was examined, since the smaller the number of tumor cells injected, the more clearly the immune defense may be observed. When 1x10(6) or 1x10(5) B16BL6 cells were injected into m...

journal_title：FEBS letters

authors： Kikkawa H,Imafuku H,Tsukada H,Oku N

更新日期：2000-02-11 00:00:00

abstract：:The RhoGTPase Rac1 is activated in a polarised fashion and controls cell motility. We previously showed that Rac1 binds the PP2A inhibitor SET and recruits nuclear SET to the cytosol. We show that a SET mutant, lacking a nuclear localization signal, SET(ΔNLS), promotes cell spreading and motility. This was accompanied...

journal_title：FEBS letters

authors： Lam BD,Anthony EC,Hordijk PL

更新日期：2013-01-16 00:00:00

abstract：:The amino acid sequence of the eclosion hormone from the tobacco hornworm Manduca sexta has been determined, using less than 500 pmol of protein and microanalytical techniques. The protein contains 62 amino acid residues and has a molecular mass of 6813 Da. The amino-terminal sequence is similar to that of a 13-residu...

journal_title：FEBS letters

authors： Marti T,Takio K,Walsh KA,Terzi G,Truman JW

更新日期：1987-07-27 00:00:00

abstract：:Poly(A)+ RNA isolated from post-mortem human hypothalami has been used to characterize the poly-protein precursors to vasopressin and oxytocin. Translation in a cell-free system and subsequent immuno-precipitation with antibodies raised against either vasopressin or neurophysin identified a product of Mr 19000 (prepro...

journal_title：FEBS letters

authors： Mohr E,Hillers M,Ivell R,Haulica ID,Richter D

更新日期：1985-11-25 00:00:00

abstract：:So far, various approaches for phylogenetic analysis have been developed. Almost all of them put stress on analyzing nucleic acid sequences or protein primary structures. In this paper, we take the physicochemical properties of amino acids into account and introduce the hydropathy profile of amino acids into phylogene...

journal_title：FEBS letters

authors： Liu N,Wang T

更新日期：2006-10-02 00:00:00

abstract：:The oleosin glycine-rich protein genes Atgrp-6, Atgrp-7, and Atgrp-8 occur in clusters in the Arabidopsis genome and are expressed specifically in the tapetum cells. The cis-regulatory regions involved in the tissue-specific gene expression were investigated by fusing different segments of the gene cluster to the uidA...

journal_title：FEBS letters

authors： Franco LO,de O Manes CL,Hamdi S,Sachetto-Martins G,de Oliveira DE

更新日期：2002-04-24 00:00:00

abstract：:Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)-kappaB transcription factor. TUCAN/CARDINAL is a recently identified CARD-containing protein involved in r...

journal_title：FEBS letters

authors： Stilo R,Leonardi A,Formisano L,Di Jeso B,Vito P,Liguoro D

更新日期：2002-06-19 00:00:00

abstract：:We have analyzed the glycosaminoglycans exposed on the surface of endothelial cells cultured in vitro. The cells were labelled with [35S]sodium sulfate. Chondroitin sulfate, heparan sulfate and dermatan sulfate are the main sulfated glycosaminoglycans present on the cell surface. They are synthesized by endothelial ce...

journal_title：FEBS letters

authors： Cavari S,Vannucchi S

更新日期：1993-05-24 00:00:00

abstract：:Caloric restriction (CR) is the most compelling example of lifespan extension by external manipulation. Although the molecular mechanisms remain unknown, the theory of hormesis has been invoked to explain the life promoting effects of CR. Hormesis is defined as the beneficial effects of low intensity stressor on a cel...

journal_title：FEBS letters

authors： Kharade SV,Mittal N,Das SP,Sinha P,Roy N

更新日期：2005-12-19 00:00:00

abstract：:Complete [1H]NMR resonance assignments are presented for the second of the three zinc fingers from SW15 as it appears in both 1- and 2-finger constructs. Signals from finger 2 are unaffected by the presence or absence of finger 1, showing that the protein has a modular construction. The structure of finger 2 comprises...

journal_title：FEBS letters

authors： Neuhaus D,Nakaseko Y,Nagai K,Klug A

更新日期：1990-03-26 00:00:00

abstract：:The purinergic receptor P2X(7) is part of a complex signaling mechanism participating in a variety of physiological and pathological processes. Depending on the activation scheme, P2X(7) receptors in vivo are non-selective cation channels or form large pores that can mediate apoptotic cell death. Expression of P2X(7)R...

journal_title：FEBS letters

authors： Locovei S,Scemes E,Qiu F,Spray DC,Dahl G

更新日期：2007-02-06 00:00:00

abstract：:We have used a panel of monoclonal antibodies in a study of the expression of multiple tubulins in Physarum polycephalum. Three anti-beta-tubulin monoclonal antibodies, DM1B, DM3B3 and KMX-1 all reacted with the beta 1-tubulin isotypes expressed in both myxamoebae and plasmodia. However, these antibodies showed a spec...

journal_title：FEBS letters

authors： Birkett CR,Foster KE,Johnson L,Gull K

更新日期：1985-08-05 00:00:00

abstract：:Preillumination of intact cells of the eukaryotic, halotolerant, cell-wall-less green alga Dunaliella salina induces a dark ATPase activity the magnitude of which is about 3-5-fold higher than the ATPase activity observed in dark-adapted cells. The light-induced activity arises from the activation and stabilization in...

journal_title：FEBS letters

authors： Selman-Reimer S,Selman BR

更新日期：1988-03-28 00:00:00

abstract：:This review focuses on the factors that regulate the proliferation of pancreatic islet beta-cells in vitro, and in particular on the intracellular pathways that convey the mitogenic signal into a proliferative response. Substances as diverse as nutrients, polypeptides, cytokines, adrenergic agents, lithium, phorbol es...

journal_title：FEBS letters

authors： Sjöholm A

更新日期：1992-10-19 00:00:00

abstract：:Endothelin-1 (ET-1) dose-dependently increased HIF1α expression in pulmonary artery smooth muscle cells (PASMCs). Inhibition of protein synthesis did not affect ET-1-induced HIF1α expression. The maximum effect of ET-1 was similar to that caused by proteasome inhibitor MG132. Further study indicates that ET-1 also dos...

journal_title：FEBS letters

authors： Li M,Liu Y,Jin F,Sun X,Li Z,Liu Y,Fang P,Shi H,Jiang X

更新日期：2012-11-02 00:00:00

abstract：:Treatment of cultured carrot cells with dibutyryl cAMP or forskolin resulted in the appreciable decrease in extracellular K+ concentration. This decrease was found to be transient and the concentration of the ion in the culture medium restored to the original level within few minutes. The cAMP-induced decrease in K+ l...

journal_title：FEBS letters

authors： Kurosaki F

更新日期：1997-05-12 00:00:00

abstract：:Sequential reverse transcription and polymerase chain reaction (RT-PCR) of the mRNA were used to investigate the expression of dopamine receptors in human peripheral blood lymphocytes. The RT-PCR products contained three types of sequences, each corresponding to those of the D5 dopamine receptor gene and the two relat...

journal_title：FEBS letters

authors： Takahashi N,Nagai Y,Ueno S,Saeki Y,Yanagihara T

更新日期：1992-12-07 00:00:00

abstract：:CDK11(p58), a 58kDa protein of the PITSLRE kinase family, plays an important role in cell cycle progression, and is closely related to cell apoptosis. To gain further insight into the function of CDK11(p58), we screened a human fetal liver cDNA library for its interacting proteins using the yeast two-hybrid system. He...

journal_title：FEBS letters

authors： Zong H,Li Z,Liu L,Hong Y,Yun X,Jiang J,Chi Y,Wang H,Shen X,Hu Y,Niu Z,Gu J

更新日期：2005-07-04 00:00:00

abstract：:Five mouse and human leptin receptors (Ob-R) have recently been identified, a long isoform (Ob-Rb), preferentially expressed in hypothalamus, and 4 short isoforms, Ob-Ra, Ob-Rc, Ob-Rd, and Ob-Re. We have identified a new short isoform in the rat, r-OB-Rf, with 6 C-terminal amino acids and a 3' untranslated region with...

journal_title：FEBS letters

authors： Wang MY,Zhou YT,Newgard CB,Unger RH

更新日期：1996-08-26 00:00:00

abstract：:MRI has the ability to generate high-contrast and high-resolution images, to obtain multiple diagnostic evaluations of organ function and morphology, and to provide multiple image planes with no risk of ionizing radiation. Recent efforts have focused on using MR technology to monitor gene delivery, to enhance gene tra...

journal_title：FEBS letters

authors： Yang X,Atalar E

更新日期：2006-05-22 00:00:00

abstract：:Organisms using the thiosulfate-oxidizing Sox enzyme system fall into two groups: group 1 forms sulfur globules as intermediates (Allochromatium vinosum), group 2 does not (Paracoccus pantotrophus). While several components of their Sox systems are quite similar, i.e. the proteins SoxXA, SoxYZ and SoxB, they differ by...

journal_title：FEBS letters

authors： Welte C,Hafner S,Krätzer C,Quentmeier A,Friedrich CG,Dahl C

更新日期：2009-04-17 00:00:00

abstract：:CHO SSF3 cells grow as a suspension culture in unmodified commercial medium with only low-molecular weight ingredients. Continuous serum-free culture unexpectedly induced expression of a low dihydrofolate reductase activity in the originally dhfr- CHO cells. Nevertheless, it was possible with methotrexate to induce am...

journal_title：FEBS letters

authors： Gandor C,Leist C,Fiechter A,Asselbergs FA

更新日期：1995-12-27 00:00:00

abstract：:The effects of mutation of residue tyrosine M210 on the primary donor bacteriochlorophylls have been investigated by near infrared FT-Raman spectroscopy in reaction centres purified from an antenna-deficient strain of Rhodobacter sphaeroides. We find that mutation at the M210 position does not significantly perturb th...

journal_title：FEBS letters

authors： Jones MR,Heer-Dawson M,Mattioli TA,Hunter CN,Robert B

更新日期：1994-02-14 00:00:00

abstract：:Criteria for the design of peptide vaccines to prevent AIDS are presented. The best vaccine candidates contain both B and T lymphocyte-defined epitopes in regions conserved in sequence between viral isolates. We propose that attention should focus on proteins specified by the gag and, possibly, pol genes in addition t...

journal_title：FEBS letters

authors： Sternberg MJ,Barton GJ,Zvelebil MJ,Cookson J,Coates AR

更新日期：1987-06-29 00:00:00

abstract：:The cDNA coding for a novel member of the cysteine-rich protein family was isolated from a rat brain cDNA library. It encodes a protein, denoted cysteine-rich protein 2 (CRP2), of 208 amino acid residues containing two tandem repeats of an unusual LIM/double zinc-finger-like motif. The ubiquitous tissue distribution a...

journal_title：FEBS letters

authors： Okano I,Yamamoto T,Kaji A,Kimura T,Mizuno K,Nakamura T

更新日期：1993-10-25 00:00:00

abstract：:The muscular content of the mRNAs encoding the five subunits of the nicotonic acetylcholine receptor was measured during postnatal development in the rat. Subunit specific mRNAs show differential regulation. The levels of the alpha-, gamma- and delta-subunit specific mRNAs decrease steadily after birth, while the beta...

journal_title：FEBS letters

authors： Witzemann V,Barg B,Criado M,Stein E,Sakmann B

更新日期：1989-01-02 00:00:00