Abstract:
:Two different isoforms of subunit VIIa have been found in cytochrome c oxidase isolated from human skeletal muscle. The first 22 residues of the N-terminal amino acid sequences showed 5 differences. Our results provide the first conclusive evidence for the existence of cytochrome c oxidase isoenzymes in man. Since the two cytochrome c oxidase isoforms were both present in skeletal muscle tissue, though not necessarily in the same cell type, this suggests that human cytochrome c oxidase isoforms are not strictly tissue-specific. These findings may have important implications for the elucidation of genetic diseases in man in which a deficiency of cytochrome c oxidase is restricted to certain tissues.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Van Beeumen JJ,Van Kuilenburg AB,Van Bun S,Van den Bogert C,Tager JM,Muijsers AOdoi
10.1016/0014-5793(90)81376-ysubject
Has Abstractpub_date
1990-04-24 00:00:00pages
213-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(90)81376-Yjournal_volume
263pub_type
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