Abstract:
:The transmembrane protein MIG-13 is a key regulator required for anterior migration of neural cells in Caenorhabditis elegans, but the signaling mechanisms involved remain unknown. Here, we isolated a suppressor mutation in the unc-71/adm-1 gene, which rescued the AVM neuron migration defect in mig-13 mutants. Genetic analyses revealed that UNC-71 at least partly acts downstream of MIG-13 and has an inhibitory effect on the anterior cell migration. The unc-71 mutation also rescued the anterior migration defect of AVM neuron in src-1 mutants. These findings suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Masuda H,Nakamura K,Takata N,Itoh B,Hirose T,Moribe H,Mekada E,Okada Mdoi
10.1016/j.febslet.2012.01.031subject
Has Abstractpub_date
2012-03-23 00:00:00pages
740-6issue
6eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00064-6journal_volume
586pub_type
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