Ca2+ binding of latent transforming growth factor-beta 1 binding protein.

Abstract:

:Latent transforming growth factor-beta 1 binding protein (LTBP) is a constituent of the latent high molecular weight complex of TGF-beta 1 in human platelets. In the present communication, we show that LTBP binds Ca2+ in its free form as well as in the latent TGF-beta 1 complex. The binding of Ca2+ induces a structural change which protects the molecule against proteolysis and changes its elution position when analyzed by anion exchange chromatography. The in vitro activation of TGF-beta 1 is not influenced by the presence of Ca2+. The possible significance of Ca2+ binding of LTBP is discussed.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Colosetti P,Hellman U,Heldin CH,Miyazono K

doi

10.1016/0014-5793(93)80079-a

subject

Has Abstract

pub_date

1993-04-05 00:00:00

pages

140-4

issue

2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(93)80079-A

journal_volume

320

pub_type

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