Abstract:
:Latent transforming growth factor-beta 1 binding protein (LTBP) is a constituent of the latent high molecular weight complex of TGF-beta 1 in human platelets. In the present communication, we show that LTBP binds Ca2+ in its free form as well as in the latent TGF-beta 1 complex. The binding of Ca2+ induces a structural change which protects the molecule against proteolysis and changes its elution position when analyzed by anion exchange chromatography. The in vitro activation of TGF-beta 1 is not influenced by the presence of Ca2+. The possible significance of Ca2+ binding of LTBP is discussed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Colosetti P,Hellman U,Heldin CH,Miyazono Kdoi
10.1016/0014-5793(93)80079-asubject
Has Abstractpub_date
1993-04-05 00:00:00pages
140-4issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(93)80079-Ajournal_volume
320pub_type
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