Abstract:
:The murine mammary FM3A/O and the thymidylate (dTMP) synthetase-deficient FM3A/TS- carcinoma cell lines can be considered as a novel and useful test system for the detection of nucleoside analogues which are directly aimed at the thymidylate synthetase. These compounds should be inhibitory for FM3A/O but not for FM3A/TS- cells, and their inhibitory effects on FM3A/O cell growth should be readily reversed by exogenous dThd within the concentration range of 5-20 microM.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Balzarini J,de Clercq E,Ayusawa D,Seno Tdoi
10.1016/0014-5793(84)81052-2subject
Has Abstractpub_date
1984-07-23 00:00:00pages
227-32issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(84)81052-2journal_volume
173pub_type
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